Metabolic activation of aromatic amines by human pancreas
نویسندگان
چکیده
منابع مشابه
Metabolic activation of aromatic amines by human pancreas.
Epidemiologic studies have suggested that aromatic amines (and nitroaromatic hydrocarbons) may be carcinogenic for human pancreas. Pancreatic tissues from 29 organ donors (13 smokers, 16 non-smokers) were examined for their ability to metabolize aromatic amines and other carcinogens. Microsomes showed no activity for cytochrome P450 (P450) 1A2-dependent N-oxidation of 4-aminobiphenyl (ABP) or f...
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In vitro metabolism and metabolic activation of 2-acetylaminofluorene (AAF), 2-aminofluorene, and 2,4-diaminoanisole to mutagenic (Salmonella test system) and covalently proteinbound intermediates were evaluated in subcellular fractions from seven human livers. The cytochrome P-450 content, aryl hydrocarbon hydroxylase activity, and sodium dodecyl sulfate: polyacrylamide gel electrophoresis of ...
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ژورنال
عنوان ژورنال: Carcinogenesis
سال: 1997
ISSN: 1460-2180
DOI: 10.1093/carcin/18.5.1085